Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint".
نویسندگان
چکیده
Müller et al. (Reports, 27 October 2006, p. 654) showed that inhibition of the gamma-tubulin ring complex (gamma-TuRC) activates the spindle assembly checkpoint (SAC), which led them to suggest that gamma-TuRC proteins play molecular roles in SAC activation. Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature.
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عنوان ژورنال:
- Science
دوره 316 5827 شماره
صفحات -
تاریخ انتشار 2006